Pour autant que je sache, non, mais les fichiers vcf.gz sont derrière un serveur http qui prend en charge Byte-Range , vous pouvez donc utiliser tabix
ou toute API associée :
$ tabix "https://storage.googleapis.com/gnomad-public/release-170228/vcf/exomes/gnomad.exomes.r2.0.1.sites.vcf.gz" "22: 17265182-17265182"
22 17265182. AT 762.04 PASS AC = 1; AF = 4,78057e-06; AN = 209180; BaseQRankSum = -4,59400e + 00; ClippingRankSum = 2,18000e + 00; DP = 4906893; FS = 1,00270e + 01; ConsanguinitéCoeff = 4,40000e-03 ; MQ = 3.15200e + 01; MQRankSum = 1.40000e + 00; QD = 1.31400e + 01; ReadPosRankSum = 2.23000e-01; SOR = 9.90000e-02; VQSLOD = -5.12800e + 00; VQSR_culprit = MQ; GQ_HIST_ALT = 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1; DP_HIST_ALT = 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0; AB_HIST_ALT = 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0; GQ_HIST_ALL = 1591 | 589 | 120 | 301 | 650 | 589 | 1854 | 2745 | 1815 | 4297 | 5061 | 2921 | 10164 | 1008 | 6489 | 1560 | 7017 | 457 | 6143 | 52950; DP_HIST_ALL = 2249 | 1418 | 6081 | 11707 | 16538 | 9514 | 28624 | 23829 | 7391 | 853 | 95 | 19 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0; AB_HIST_ALL = 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0; AC_AFR = 0; AC_AMR = 0; AC_ASJ = 0; AC_EAS = 0; AC_FIN = 1; AC_NFE = 0; AC_OTH = 0; AC_SAS = 0; AC_Male = 1; AC_Female = 0; AN_AFR = 11994; AN_AMR = 31324; AN_ASJ = 7806; AN_EAS = 13112; AN_FIN = 20076; AN_NFE = 94516; AN_OTH = 4656; AN_SAS = 25696; AN_Male = 114366; AN_Female = 94814; AF_AFR = 0,00000e + 00; AF_AMR = 0,00000e + 00; AF_ASJ = 0,00000e + 00 ; AF_EAS = 0,00000e + 00; A F_FIN = 4,98107e-05; AF_NFE = 0,00000e + 00; AF_OTH = 0,00000e + 00; AF_SAS = 0,00000e + 00; AF_Male = 8,74386e-06; AF_Female = 0,00000e + 00; GC_AFR = 5997,0,0; GC_AMR = 15662,0,0; GC_ASJ = 3903,0,0; GC_EAS = 6556,0,0; GC_FIN = 10037,1,0; GC_NFE = 47258,0,0; GC_OTH = 2328,0,0; GC_SAS = 12848,0,0; GC_Male = 57182,1,0; GC_Female = 47407,0,0; AC_raw = 1; AN_raw = 216642; AF_raw = 4.61591e-06; GC_raw = 108320,1,0; GC = 104589,1 , 0; Hom_AFR = 0; Hom_AMR = 0; Hom_ASJ = 0; Hom_EAS = 0; Hom_FIN = 0; Hom_NFE = 0; Hom_OTH = 0; Hom_SAS = 0; Hom_Male = 0; Hom_Female = 0; Hom_raw = 0; Hom = 0 ; POPMAX = FIN; AC_POPMAX = 1; AN_POPMAX = 20076; AF_POPMAX = 4.98107e-05; DP_MEDIAN = 58; DREF_MEDIAN = 5.01187e-84; GQ_MEDIAN = 99; AB_MEDIAN = 6.03448e-01; AS_RF_Filter = 9.18451eFiltre = PASS; CSQ = T | missense_variant | MODERATE | XKR3 | ENSG00000172967 | Transcription | ENST00000331428 | protein_coding | 4/4 || ENST00000331428.5: c.707T>A | ENSP00000331704.5: p.Phe2 707.5: p. Y | tTc / tAc || 1 || -1 || SNV | 1 | HGNC | 28778 | OUI ||| CCDS42975.1 | ENSP00000331704 | Q5GH77 || UPI000013EFAE || délétère (0) | bénin (0,055) | hmmpanther: PTHR14297&hmmpanther: PTHR14297: SF7&Pfam_domain: PF09815 ||||||||||||||||||||||||||||||| |||||||||| 1 |||| SNV | 1 |||||||||||||||||||||||||||||||| ||||||||||||, T | regulier_region_variant | MODIFIER ||| RegulatoryFeature | ENSR00001729562 | CTCF_binding_site |||||||||||| 1 |||| SNV | 1 |||| |||||||||||||||||||||||||||||||||||||||
UPDATE : 2019: le serveur actuel de gnomad ne prend pas en charge les requêtes Byte-Range.